IOCB Prague

Cryogenic Electron Microscopy

Tomáš Kouba Group
Research-Service Group
CHEM cluster

About our group

The cryogenic electron microscopy (cryo-EM) laboratory provides 3D structural analysis of proteins and their complexes. The cryo-EM laboratory thus closely cooperates with the IOCB Prague biological groups in the field of structural biology. The team provides expertise in the field of cryo-EM sample preparation and characterization, and cryo-EM data collection. In collaboration with the high-performance computing group, we provide 3D analysis of cryo-EM data at the local computing cluster. Last but not least, we provide expertise in building atomic models of analyzed proteins and their complexes. The research focus of the cryo-EM laboratory is structural biology of viral and bacterial RNA polymerases and their inhibitors.